Neuropeptide Y receptors in GtoPdb v.2023.1

Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [158]) are activated endogenous peptides neuropeptide Y, Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified Y3 has been CXCR4 chemokine recepter (originally named LESTR, [139]). y6 is a functional gene product in mouse, absent rat, but contains frame-shift mutation primates producing truncated non-functional [84]. Three-dimensional structures have determined for subtype active Y1, Y2 Y4 [211, 114] inactive antagonist bound Y1 [240, 210]. Many of agonists exhibit differing degrees selectivity dependent species examined. For example, potency PP greater at rat than human [62]. In addition, many lack individual subtypes, can comparable against pairs NPY or not examined activity all subtypes. [125I]-PYY [125I]-NPY be used to label Y2, Y5 subtypes non-selectively, while [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP may preferentially (note that cPP denotes chicken sequence hPP sequence).